产品
编 号：F622735
分子式：C26H23NO2
分子量：381.47
分子式：C26H23NO2
分子量：381.47
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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结构图
CAS No: 1564249-38-2
产品详情
生物活性：
BJE6-106 (B106) is a potent, selective 3rd generation PKCδ inhibitor with an IC50 of 0.05 μM and targets selectivity over classical PKC isozyme PKCα (IC50=50 μM). BJE6-106 (B106) induces caspase-dependent apoptosis. BJE6-106 (B106) possesses tumor-specific effect.
体外研究：
BJE6-106 (B106) (0.2 μM, 0.5 μM;24-72 hours) suppresses cell survival in melanoma cell lines with NRAS mutations.BJE6-106 (B106) (0.2 μM, 0.5 μM;6-24 hours) triggers caspase-dependent apoptosis, increases the activity of caspase 3/7, the effect of B106 is greater than rottlerin (10-fold) in SBcl2 cells.BJE6-106 (B106) (0.5 μM;2-10 hours) activates the MKK4-JNK-H2AX Pathway by inducing MKK4, JNK and H2AX activation at different times in SBcl2 cells.
BJE6-106 (B106) is a potent, selective 3rd generation PKCδ inhibitor with an IC50 of 0.05 μM and targets selectivity over classical PKC isozyme PKCα (IC50=50 μM). BJE6-106 (B106) induces caspase-dependent apoptosis. BJE6-106 (B106) possesses tumor-specific effect.
体外研究：
BJE6-106 (B106) (0.2 μM, 0.5 μM;24-72 hours) suppresses cell survival in melanoma cell lines with NRAS mutations.BJE6-106 (B106) (0.2 μM, 0.5 μM;6-24 hours) triggers caspase-dependent apoptosis, increases the activity of caspase 3/7, the effect of B106 is greater than rottlerin (10-fold) in SBcl2 cells.BJE6-106 (B106) (0.5 μM;2-10 hours) activates the MKK4-JNK-H2AX Pathway by inducing MKK4, JNK and H2AX activation at different times in SBcl2 cells.
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