产品
编 号：F622464
分子式：C29H26ClF4N3O5S2
分子量：672.11
分子式：C29H26ClF4N3O5S2
分子量：672.11
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CAS No: 1631164-24-3
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生物活性：
BAY-784 is a gonadotropin releasing hormone receptor (GnRH-R) antagonist probe with IC50s of 21 and 24 nM for human and rat GnRH-R, respectively.
体内研究：
BAY-784 (0.5, 3, 10, and 30 mg/kg; 24 hours; single p.o.) suppresses the plasma luteinizing hormone (LH) concentration inovariectomized (OVX) rats in a dose-dependent manner.Animal Model:OVX rats
Dosage:0.5, 3, 10, and 30 mg/kg (Pharmacokinetic Analysis)
Administration:Single p.o.
Result:ED50=4.5 mg/kg (4/8 h).The t1/2=13-17 h, 18 h, and 7 h for male Wistar rat, female beagle, and female cynomolgus, respectively.
BAY-784 is a gonadotropin releasing hormone receptor (GnRH-R) antagonist probe with IC50s of 21 and 24 nM for human and rat GnRH-R, respectively.
体内研究：
BAY-784 (0.5, 3, 10, and 30 mg/kg; 24 hours; single p.o.) suppresses the plasma luteinizing hormone (LH) concentration inovariectomized (OVX) rats in a dose-dependent manner.Animal Model:OVX rats
Dosage:0.5, 3, 10, and 30 mg/kg (Pharmacokinetic Analysis)
Administration:Single p.o.
Result:ED50=4.5 mg/kg (4/8 h).The t1/2=13-17 h, 18 h, and 7 h for male Wistar rat, female beagle, and female cynomolgus, respectively.
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