产品
编 号：F622305
分子式：C25H22FNO4
分子量：419.44
分子式：C25H22FNO4
分子量：419.44
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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结构图
CAS No: 1664335-55-0
产品详情
生物活性：
TAK-615 is a negative allosteric modulator (NAM) of the LPA1 receptor for the research of pulmonary fibrosis. TAK-615 binds the LPA1 receptor with high affinity (Kd high affinity of 1.7 nM and Kd low affinity of 14.5 nM).
体外研究：
TAK-615 specifically binds to membranes expressing the human LPA1 receptor with estimated Kd high affinity (KdHi) of 1.7±0.5?nM and Kd low affinity (KdLo) of 14.5±12.1?nM. TAK-615 is only able to partially inhibit the LPA response (~?40% at 10?μM with an IC50 of 23±13?nM in β-arrestin assay; 60% at 10?μM, IC50 of 91±30?nM in calcium mobilisation assay) .
TAK-615 is a negative allosteric modulator (NAM) of the LPA1 receptor for the research of pulmonary fibrosis. TAK-615 binds the LPA1 receptor with high affinity (Kd high affinity of 1.7 nM and Kd low affinity of 14.5 nM).
体外研究：
TAK-615 specifically binds to membranes expressing the human LPA1 receptor with estimated Kd high affinity (KdHi) of 1.7±0.5?nM and Kd low affinity (KdLo) of 14.5±12.1?nM. TAK-615 is only able to partially inhibit the LPA response (~?40% at 10?μM with an IC50 of 23±13?nM in β-arrestin assay; 60% at 10?μM, IC50 of 91±30?nM in calcium mobilisation assay) .
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