产品
编 号:F622291
分子式:C111H169N31O35S8
分子量:2754.24
产品类型
结构图
CAS No: 1676104-75-8
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产品详情
生物活性:
Hepcidin-1 (mouse) is an endogenous peptide hormone involved in the regulation of iron homeostasis. Hepcidin-1 (mouse) upregulates mRNA levels of TRAP, cathepsin K, and MMP-9 and increases TRAP-5b protein secretion. Hepcidin-1 (mouse) downregulates the level of FPN1 protein and increases intracellular iron. Hepcidin-1 (mouse) facilitates osteoclast differentiation.
体外研究:
Hepcidin-1 mouse (200-800 nM,4 天) 促进 RANKL (50 ng/mL) 诱导的 raw264.7 细胞分化。Hepcidin-1 mouse (0-800 nM,4 天) 上调 TRAP、CTK 和 MMP-9 mRNA 的表达。Hepcidin-1 mouse (0-800 nM,20 小时) 会增加 RAW264.7 细胞中 Trap-5b 蛋白的水平并降低铁转运蛋白 1 (FPN1) 蛋白。