产品
编 号:F066715
分子式:C22H31N5O5
分子量:445.51
产品类型
结构图
CAS No: 119670-30-3
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产品详情
生物活性:
Z-LVG-CHN2 is a cell-permeable and irreversible inhibitor of cysteine proteinase. Z-LVG-CHN2 is a tripeptide derivative and mimics part of the human cysteine proteinase-binding center. Z-LVG-CHN2 displays an inhibition on HSV whereas no significant effect on poliovirus replication. Z-LVG-CHN2 effectively blocks SARS-COV-2 replication (EC50=190 nM) via inhibition of SARS-COV-2 3CL pro protease.
体外研究:
Z-LVG-CHN2 (0-10 μM;预处理 16 小时) 在 Vero E6 细胞中以可辨别的剂量依赖性方式抑制抗病毒活性,旨在捕获多周期复制,表现出 EC50 值为 0.19 μM。