产品
编 号：F622120
分子式：C22H29Cl2N3O
分子量：422.39
分子式：C22H29Cl2N3O
分子量：422.39
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CAS No: 1782532-06-2
产品详情
生物活性：
PD 168568 dihydrochloride is a orally active and potent dopamine receptor D4 (DRD4) antagonist. PD 168568 dihydrochloride contains an isoindolinone and is selective for the D4 receptor versus D2 and D3, with Ki values of 8.8, 1842, and 2682 nM, respectively. PD 168568 dihydrochloride can be used for glioblastoma (GBM) research.
体内研究：
PD 168568 dihydrochloride (3 mg/kg，口服) 可抑制大鼠 amphetamine 刺激的运动活动。Animal Model:Rat
Dosage:3 mg/kg
Administration:Oral administration
Result:Inhibit amphetamine (0.5 mg/kg, i.p.) stimulated locomotor activity.
体外研究：
PD 168568 dihydrochloride 对胶质母细胞瘤神经干细胞 (GNS) 表现出选择性抑制，IC50 为 25-50 μM。
PD 168568 dihydrochloride is a orally active and potent dopamine receptor D4 (DRD4) antagonist. PD 168568 dihydrochloride contains an isoindolinone and is selective for the D4 receptor versus D2 and D3, with Ki values of 8.8, 1842, and 2682 nM, respectively. PD 168568 dihydrochloride can be used for glioblastoma (GBM) research.
体内研究：
PD 168568 dihydrochloride (3 mg/kg，口服) 可抑制大鼠 amphetamine 刺激的运动活动。Animal Model:Rat
Dosage:3 mg/kg
Administration:Oral administration
Result:Inhibit amphetamine (0.5 mg/kg, i.p.) stimulated locomotor activity.
体外研究：
PD 168568 dihydrochloride 对胶质母细胞瘤神经干细胞 (GNS) 表现出选择性抑制，IC50 为 25-50 μM。
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