产品
编 号：F621922
分子式：C15H12ClN3O
分子量：285.73
分子式：C15H12ClN3O
分子量：285.73
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
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5mg
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10mg
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25mg
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结构图
CAS No: 1807758-81-1
产品详情
生物活性：
SIRT7 inhibitor 97491, a potent SIRT7 inhibitor with an IC50 of 325 nM, reduces deacetylase activity of SIRT7 in a dose-dependent manner. SIRT7 inhibitor 97491 prevents tumor progression by increasing p53 stability through acetylation at K373/382. SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway..
体内研究：
SIRT7 inhibitor 97491 (2 mg/kg；腹膜内注射；持续 3 周，周末除外) 抑制异种移植小鼠的肿瘤生长。Animal Model:Balb/c nude mice (18-20 g; 6-8 weeks old) with MES-SA cells
Dosage:2 mg/kg
Administration:Intraperitoneally injected; for 3 weeks, except on weekends.
Result:Inhibited cancer growth in vivo.
体外研究：
SIRT7 inhibitor 97491 (1-10 μM) 在 MES-SA 细胞中减少细胞生长，而不会在 HEK293 细胞中引起细胞毒性。
SIRT7 inhibitor 97491, a potent SIRT7 inhibitor with an IC50 of 325 nM, reduces deacetylase activity of SIRT7 in a dose-dependent manner. SIRT7 inhibitor 97491 prevents tumor progression by increasing p53 stability through acetylation at K373/382. SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway..
体内研究：
SIRT7 inhibitor 97491 (2 mg/kg；腹膜内注射；持续 3 周，周末除外) 抑制异种移植小鼠的肿瘤生长。Animal Model:Balb/c nude mice (18-20 g; 6-8 weeks old) with MES-SA cells
Dosage:2 mg/kg
Administration:Intraperitoneally injected; for 3 weeks, except on weekends.
Result:Inhibited cancer growth in vivo.
体外研究：
SIRT7 inhibitor 97491 (1-10 μM) 在 MES-SA 细胞中减少细胞生长，而不会在 HEK293 细胞中引起细胞毒性。
产品资料
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