产品
编 号：F621902
分子式：C28H26F3N7O2
分子量：549.55
分子式：C28H26F3N7O2
分子量：549.55
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CAS No: 1808287-83-3
产品详情
生物活性：
CHMFL-ABL-053 (Compound 18a) is a potent, selective, and orally available BCR-ABL, SRC and p38 kinase inhibitor with IC50 values of 70, 90 and 62 nM against ABL1, SRC and p38, respectively.
体内研究：
CHMFL-ABL-053 (Compound 18a) (50 mg/kg/day) almost completely suppresses tumor progression in the K562 cells inoculated xenograft mouse model.
体外研究：
CHMFL-ABL-053 (Compound 18a) inhibits the proliferation of CML cell lines with GI50 of 14, 25 and 16 nM against K562, KU812 and MEG-01, respectively.
CHMFL-ABL-053 (Compound 18a) is a potent, selective, and orally available BCR-ABL, SRC and p38 kinase inhibitor with IC50 values of 70, 90 and 62 nM against ABL1, SRC and p38, respectively.
体内研究：
CHMFL-ABL-053 (Compound 18a) (50 mg/kg/day) almost completely suppresses tumor progression in the K562 cells inoculated xenograft mouse model.
体外研究：
CHMFL-ABL-053 (Compound 18a) inhibits the proliferation of CML cell lines with GI50 of 14, 25 and 16 nM against K562, KU812 and MEG-01, respectively.
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