产品
编 号：F621898
分子式：C18H15ClFN5O2
分子量：387.8
分子式：C18H15ClFN5O2
分子量：387.8
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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结构图
CAS No: 1809085-30-0
产品详情
生物活性：
VU0650786 is a potent and selective CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3 NAM), with an IC50 of 392 nM. VU0650786 has antidepressant and anxiolytic activity in rodents.
体内研究：
VU0650786 (VU786) (i.p., 30 mg/kg) increases the proportion of c-Fos-positive cells by approximately 4-fold, enhances synaptic strength in cone cell subpopulations, weakens thalamocortical long-term depression (LTD), and reduces passive coping in acute models of antidepressant-like activity in inducible cFos-EGFP mice.The pharmacokinetic parameters of VU0650786 (compound 106) in rats. ParametersIV (0.2 mg/kg)
t1/2 (min)42
CL plasma (mL/min/kg)37
VSS (L/kg)1.6
VU0650786 is a potent and selective CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3 NAM), with an IC50 of 392 nM. VU0650786 has antidepressant and anxiolytic activity in rodents.
体内研究：
VU0650786 (VU786) (i.p., 30 mg/kg) increases the proportion of c-Fos-positive cells by approximately 4-fold, enhances synaptic strength in cone cell subpopulations, weakens thalamocortical long-term depression (LTD), and reduces passive coping in acute models of antidepressant-like activity in inducible cFos-EGFP mice.The pharmacokinetic parameters of VU0650786 (compound 106) in rats. ParametersIV (0.2 mg/kg)
t1/2 (min)42
CL plasma (mL/min/kg)37
VSS (L/kg)1.6
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