产品
编 号：F621808
分子式：C20H15ClN2O3
分子量：366.8
分子式：C20H15ClN2O3
分子量：366.8
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CAS No: 1821638-43-0
产品详情
生物活性：
LUF7244 is a selective allosteric modulator of Kv11.1 channels. LUF7244 inhibits early afterdepolarizations. LUF7244 can be used for anti-arrhythmia research.
体内研究：
LUF7244 (2.5 mg/kg; i.v.; for 15 min) decreases repolarization parameters. LUF7244 has antiarrhythmic effects against dofetilide-induced TdP arrhythmias in CAVB dogs.
体外研究：
LUF7244 (0-10 μM; HEK293 cells) binds Kv11.1 channels and increases IKv11.1 by inhibiting inactivation in a dose-dependent manner.LUF7244 (0-10 μM; cardiomyocytes) reduces action potential duration (APD) by approximately 50% and dofetilide-induced early afterdepolarization (EAD) in isolated ventricular CMCs from SR and CAVB dogs.LUF7244 (10 μM) had no effects on IKIR2.1, INav1.5, ICa-L, and IKs but doubled IKr.
LUF7244 is a selective allosteric modulator of Kv11.1 channels. LUF7244 inhibits early afterdepolarizations. LUF7244 can be used for anti-arrhythmia research.
体内研究：
LUF7244 (2.5 mg/kg; i.v.; for 15 min) decreases repolarization parameters. LUF7244 has antiarrhythmic effects against dofetilide-induced TdP arrhythmias in CAVB dogs.
体外研究：
LUF7244 (0-10 μM; HEK293 cells) binds Kv11.1 channels and increases IKv11.1 by inhibiting inactivation in a dose-dependent manner.LUF7244 (0-10 μM; cardiomyocytes) reduces action potential duration (APD) by approximately 50% and dofetilide-induced early afterdepolarization (EAD) in isolated ventricular CMCs from SR and CAVB dogs.LUF7244 (10 μM) had no effects on IKIR2.1, INav1.5, ICa-L, and IKs but doubled IKr.
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