产品
编 号：F621437
分子式：C38H37F3N6O3
分子量：682.73
分子式：C38H37F3N6O3
分子量：682.73
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 1931946-73-4
产品详情
生物活性：
PC945, a potent, long-acting antifungal triazole, possesses activity against a broad range of both azole-susceptible and azole-resistant strains of Aspergillus fumigatus. PC945 is also a potent, tightly binding inhibitor of A. fumigatus sterol 14α-demethylase activity, CYP51A and CYP51B, with IC50s of 0.23 μM and 0.22 μM, respectively.
体内研究：
PC945 (0.56-14 μg/mouse; intranasal; daily for 7 days) substantially inhibits the incidence of rolling behavior.Animal Model:Specific-pathogen-free A/J mice (male, 5 weeks old, pulmonary Aspergillus infection)
Dosage:0.56, 2.8, 14 μg/mouse (intranasal application of 0.016-, 0.08-, and 0.4-mg/ml suspensions, respectively)
Administration:Intranasal; daily for 7 days
Result:Substantially inhibited the incidence of rolling behavior.
体外研究：
PC945 is a triazole antifungal designed for administration via inhalation.PC945 exhibits the most potent antifungal activity on azole-susceptible strain NCPF2010 with the MIC value of 0.063?μg/mL.
PC945, a potent, long-acting antifungal triazole, possesses activity against a broad range of both azole-susceptible and azole-resistant strains of Aspergillus fumigatus. PC945 is also a potent, tightly binding inhibitor of A. fumigatus sterol 14α-demethylase activity, CYP51A and CYP51B, with IC50s of 0.23 μM and 0.22 μM, respectively.
体内研究：
PC945 (0.56-14 μg/mouse; intranasal; daily for 7 days) substantially inhibits the incidence of rolling behavior.Animal Model:Specific-pathogen-free A/J mice (male, 5 weeks old, pulmonary Aspergillus infection)
Dosage:0.56, 2.8, 14 μg/mouse (intranasal application of 0.016-, 0.08-, and 0.4-mg/ml suspensions, respectively)
Administration:Intranasal; daily for 7 days
Result:Substantially inhibited the incidence of rolling behavior.
体外研究：
PC945 is a triazole antifungal designed for administration via inhalation.PC945 exhibits the most potent antifungal activity on azole-susceptible strain NCPF2010 with the MIC value of 0.063?μg/mL.
产品资料
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