产品
编 号：F621377
分子式：C22H31NO3
分子量：357.49
分子式：C22H31NO3
分子量：357.49
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CAS No: 1949726-13-9
产品详情
生物活性：
PM226 is a selective cannabinoid CB2R agonist (Ki (CB2R)=13 nM; EC50 (CB2R)=39 nM; Ki (CB1R) >40 μM;) with neuroprotective properties in vitro and vivo.
体内研究：
PM226 (0.1, 1 and 10 mg/kg; administered i.p.) administration decreases the volume of the striatal lesion caused by Malonate.Animal Model:Malonate-lesioned adult (12 week old; 350-400 g) male Wistar rats
Dosage:0.1, 1 and 10 mg/kg
Administration:Administered i.p.
Result:Reduced the volume of edema observed in Malonate-lesioned rats at the dose of 1 mg/kg.
体外研究：
PM226 binds selectively to CB2 receptor with an affinity in the nanomolar range (Ki=12.8±2.4 nM). PM226 has negligible affinity for the CB1 receptor (Ki >40000 nM) and no activity at the GPR55. PM226 was also evaluated in GTPγS binding assays specific to the CB2 receptor showing agonist activity (EC50=38.67±6.70 nM).
PM226 is a selective cannabinoid CB2R agonist (Ki (CB2R)=13 nM; EC50 (CB2R)=39 nM; Ki (CB1R) >40 μM;) with neuroprotective properties in vitro and vivo.
体内研究：
PM226 (0.1, 1 and 10 mg/kg; administered i.p.) administration decreases the volume of the striatal lesion caused by Malonate.Animal Model:Malonate-lesioned adult (12 week old; 350-400 g) male Wistar rats
Dosage:0.1, 1 and 10 mg/kg
Administration:Administered i.p.
Result:Reduced the volume of edema observed in Malonate-lesioned rats at the dose of 1 mg/kg.
体外研究：
PM226 binds selectively to CB2 receptor with an affinity in the nanomolar range (Ki=12.8±2.4 nM). PM226 has negligible affinity for the CB1 receptor (Ki >40000 nM) and no activity at the GPR55. PM226 was also evaluated in GTPγS binding assays specific to the CB2 receptor showing agonist activity (EC50=38.67±6.70 nM).
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