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编 号:F621360
分子式:C18H18N4O4
分子量:354.36
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10mM*1mL in DMSO
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1mg
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5mg
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10mg
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生物活性:
Nesolicaftor (PTI-428) is a specific cystic fibrosis transmembrane conductance regulator (CFTR) amplifier.

体外研究:
Nesolicaftor (PTI-428) (30 μM, 24 h) can increase CFTR function, such as causing a larger change in inh-172 in 16HBE14o-cells expressing G542X-CFTR, also can increase in F508del-CFTR function of CFBE41o-cells expressing F508del-CFTR in a dose-dependent manner.
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