产品
编 号：F621059
分子式：C28H35FN4O
分子量：462.6
分子式：C28H35FN4O
分子量：462.6
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
结构图
CAS No: 2056014-40-3
产品详情
生物活性：
BLM-IN-1 is an effective bloom syndrome protein (BLM) inhibitor. BLM-IN-1 has a high binding affinity with a KD valueof 1.81 μM. BLM-IN-1 has good inhibitory effect for BLM with an IC50 value of 0.95 μM. BLM-IN-1 can induce cell apoptosis. BLM-IN-1can be used for the research of DNA damage and cancer.
体外研究：
BLM-IN-1 (compound 29) has a strong BLM binding with a KD of 1.81 μM.BLM-IN-1 can inhibit BLM with an IC50 of 0.95 μM.BLM-IN-1 (1.0 μM) inhibits the unwinding activity of BLM but also disrupt the BLM binding to DNA.BLM-IN-1 (0-1.0 μM) regulates the homologous recombination by disrupting the recruitment of BLM to DSB sites.BLM-IN-1 (1.0, 2.0 μM; 48 h) induces DNA damage response and apoptosis.BLM-IN-1 (0.1, 1.0, 2.0 μM; 48 h) induces proliferation arrest and synthetic interaction.
BLM-IN-1 is an effective bloom syndrome protein (BLM) inhibitor. BLM-IN-1 has a high binding affinity with a KD valueof 1.81 μM. BLM-IN-1 has good inhibitory effect for BLM with an IC50 value of 0.95 μM. BLM-IN-1 can induce cell apoptosis. BLM-IN-1can be used for the research of DNA damage and cancer.
体外研究：
BLM-IN-1 (compound 29) has a strong BLM binding with a KD of 1.81 μM.BLM-IN-1 can inhibit BLM with an IC50 of 0.95 μM.BLM-IN-1 (1.0 μM) inhibits the unwinding activity of BLM but also disrupt the BLM binding to DNA.BLM-IN-1 (0-1.0 μM) regulates the homologous recombination by disrupting the recruitment of BLM to DSB sites.BLM-IN-1 (1.0, 2.0 μM; 48 h) induces DNA damage response and apoptosis.BLM-IN-1 (0.1, 1.0, 2.0 μM; 48 h) induces proliferation arrest and synthetic interaction.
产品资料
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