产品
编 号：F621020
分子式：C20H32ClN3O
分子量：365.94
分子式：C20H32ClN3O
分子量：365.94
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
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1mg
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 2070014-88-7
产品详情
生物活性：
SRI-011381 hydrochloride is an orally active TGF-β signaling agonist, exhibits neuroprotective effects.
体内研究：
SRI-011381 (30 mg/kg; i.p.; every 2 d; for 22 days) hydrochloride partially rescues the deficits in optic nerve and retina of YAPGFAP-CKO EAE mice.Animal Model:YAPGFAP-CKO mice bearing experimental autoimmune encephalomyelitis (EAE)
Dosage:30 mg/kg
Administration:Intraperitoneally injection; every 2 d; for 22 days
Result:Significantly inhibited inflammatory infiltration and relieved the loss of neurons in YAPGFAP-CKO EAE mice.
体外研究：
SRI-011381 (10 μM) hydrochloride promotes the proliferation of mouse lung fibroblasts, and significantly increases TGF-β1, NALP3, collagen-1, and α-SMA expression.
SRI-011381 hydrochloride is an orally active TGF-β signaling agonist, exhibits neuroprotective effects.
体内研究：
SRI-011381 (30 mg/kg; i.p.; every 2 d; for 22 days) hydrochloride partially rescues the deficits in optic nerve and retina of YAPGFAP-CKO EAE mice.Animal Model:YAPGFAP-CKO mice bearing experimental autoimmune encephalomyelitis (EAE)
Dosage:30 mg/kg
Administration:Intraperitoneally injection; every 2 d; for 22 days
Result:Significantly inhibited inflammatory infiltration and relieved the loss of neurons in YAPGFAP-CKO EAE mice.
体外研究：
SRI-011381 (10 μM) hydrochloride promotes the proliferation of mouse lung fibroblasts, and significantly increases TGF-β1, NALP3, collagen-1, and α-SMA expression.
产品资料
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