产品
编 号：F620611
分子式：C23H19F6N5O3
分子量：527.42
分子式：C23H19F6N5O3
分子量：527.42
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
结构图
CAS No: 2162961-71-7
产品详情
生物活性：
BI-2545 is a potent autotaxin (ATX) inhibitor that significantly reduces LPA, with IC50s of 2.2 nM and 3.4 nM for human ATX and rat ATX, respectively.
体内研究：
BI-2545 (10 mg/kg; p.o.) has high and sustained in vivo efficacy in reducing LPAs.BI-2545 (10 mg/kg; p.o.) has a half-life of t1/2=3.4 hours.Animal Model:Rat
Dosage:10 mg/kg
Administration:Oral administration
Result:Reduces the sum of the plasma LPA species up to 90%.
体外研究：
BI-2545 displays good potency in the LPA and rat whole blood assay with IC50s of 29 nM and 96 nM, respectively.
BI-2545 is a potent autotaxin (ATX) inhibitor that significantly reduces LPA, with IC50s of 2.2 nM and 3.4 nM for human ATX and rat ATX, respectively.
体内研究：
BI-2545 (10 mg/kg; p.o.) has high and sustained in vivo efficacy in reducing LPAs.BI-2545 (10 mg/kg; p.o.) has a half-life of t1/2=3.4 hours.Animal Model:Rat
Dosage:10 mg/kg
Administration:Oral administration
Result:Reduces the sum of the plasma LPA species up to 90%.
体外研究：
BI-2545 displays good potency in the LPA and rat whole blood assay with IC50s of 29 nM and 96 nM, respectively.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备