产品
编 号：F619132
分子式：C13H16ClN3O3
分子量：297.74
分子式：C13H16ClN3O3
分子量：297.74
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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50mg
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结构图
CAS No: 2225836-30-4
产品详情
生物活性：
ACH-000143 is a potent and orally active melatonin receptor agonist, with EC50 values of 0.06 nM and 0.32 nM for MT1 and MT2, respectively.
体内研究：
ACH-000143 reduces liver triglycerides and steatosis in diet-Induced obese rats.ACH-000143 is devoid of hERG binding, genotoxicity, and behavioral alterations at doses up to 100 mg/kg p.o., supporting further investigation of this compound as a drug candidate.ACH-000143 significantly reduces plasma glucose at 10 mg/kg (?16.4%, p < 0.05) and 30 mg/kg (?16.9%, p < 0.01).Animal Model:High-fat diet rats.
Dosage:10 and 30 mg/kg.
Administration:Orally, once daily for two months.
Result:Significantly reduced the weekly BW gain on weeks.
ACH-000143 is a potent and orally active melatonin receptor agonist, with EC50 values of 0.06 nM and 0.32 nM for MT1 and MT2, respectively.
体内研究：
ACH-000143 reduces liver triglycerides and steatosis in diet-Induced obese rats.ACH-000143 is devoid of hERG binding, genotoxicity, and behavioral alterations at doses up to 100 mg/kg p.o., supporting further investigation of this compound as a drug candidate.ACH-000143 significantly reduces plasma glucose at 10 mg/kg (?16.4%, p < 0.05) and 30 mg/kg (?16.9%, p < 0.01).Animal Model:High-fat diet rats.
Dosage:10 and 30 mg/kg.
Administration:Orally, once daily for two months.
Result:Significantly reduced the weekly BW gain on weeks.
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