产品
编 号：F619127
分子式：C21H28ClN7O
分子量：429.95
分子式：C21H28ClN7O
分子量：429.95
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
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询价
5mg
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10mg
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询价
结构图
CAS No: 2226201-97-2
产品详情
生物活性：
KSC-34, a covalent modifier of protein disulfide isomerase A1 (PDIA1), is also a selective and potent a-site inhibitor of PDIA1 with an IC50 of 3.5 μM. KSC-34 displays a 30-fold selectivity for a domain over a′ domain and displays high selectivity for PDIA1 in complex proteomes with minimal engagement of other members of the PDI family. KSC-34 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
体外研究：
KSC-34 对 PDIA1 的选择性高于 PDI 家族的其他成员和其他细胞含半胱氨酸的蛋白质。KSC-34 包含一个 (4-苯基丁基) 甲胺多样性元素，用于优化与 PDIA1 结构域活性位点的结合，以及用于共价修饰 PDIA1 上 C53 的氯乙酰胺。
KSC-34, a covalent modifier of protein disulfide isomerase A1 (PDIA1), is also a selective and potent a-site inhibitor of PDIA1 with an IC50 of 3.5 μM. KSC-34 displays a 30-fold selectivity for a domain over a′ domain and displays high selectivity for PDIA1 in complex proteomes with minimal engagement of other members of the PDI family. KSC-34 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
体外研究：
KSC-34 对 PDIA1 的选择性高于 PDI 家族的其他成员和其他细胞含半胱氨酸的蛋白质。KSC-34 包含一个 (4-苯基丁基) 甲胺多样性元素，用于优化与 PDIA1 结构域活性位点的结合，以及用于共价修饰 PDIA1 上 C53 的氯乙酰胺。
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