产品
编 号：F619108
分子式：C10H7Cl4N3
分子量：310.99
分子式：C10H7Cl4N3
分子量：310.99
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CAS No: 2227372-56-5
产品详情
生物活性：
Loreclezole hydrochloride, an antiepileptic compound, is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit containing receptors.
体内研究：
Loreclezole (10, 25, 50 or 75 mg/kg, i.p. 60 min before measurement of seizure threshold ) results in a dosedependent rise in seizure threshold as measured by the dose of pentylenetetrazolrequired to produce a convulsion 60 min later. Loreclezole also has the least effect on loss of muscle tone as measured by the “pull-up” test.Animal Model:Adult male Lister Hooded rats.
Dosage:10, 25, 50 or 75 mg/kg.
Administration:IP, 60 min before measurement of seizure threshold.
Result:Resulted in a dosedependent rise in seizure threshold as measured by the dose of pentylenetetrazolrequired to produce a convulsion 60 min later.
Loreclezole hydrochloride, an antiepileptic compound, is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit containing receptors.
体内研究：
Loreclezole (10, 25, 50 or 75 mg/kg, i.p. 60 min before measurement of seizure threshold ) results in a dosedependent rise in seizure threshold as measured by the dose of pentylenetetrazolrequired to produce a convulsion 60 min later. Loreclezole also has the least effect on loss of muscle tone as measured by the “pull-up” test.Animal Model:Adult male Lister Hooded rats.
Dosage:10, 25, 50 or 75 mg/kg.
Administration:IP, 60 min before measurement of seizure threshold.
Result:Resulted in a dosedependent rise in seizure threshold as measured by the dose of pentylenetetrazolrequired to produce a convulsion 60 min later.
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