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编 号：F619080
分子式：C20H19ClN4O
分子量：366.84
分子式：C20H19ClN4O
分子量：366.84
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CAS No: 2230253-82-2
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生物活性：
PKI-166 hydrochloride is a potent, selective and orally active EGFR tyrosine kinase inhibitor, with an IC50 of 0.7 nM.
体内研究：
PKI-166 hydrochloride (100 mg/kg; p.o.; daily; for 29 days) inhibits of pancreatic cancer growth.Animal Model:Male athymic nude mice with L3.6pl cells xenograft (8-12 weeks)
Dosage:100 mg/kg
Administration:Oral administration; daily; for 29 days
Result:Significantly decreased median tumor volume.
体外研究：
PKI-166 hydrochloride (0-0.5 μM; 1 hour; pretreatment) inhibits EGFR autophosphorylation in human pancreatic cancer cells.PKI-166 hydrochloride (0.03 μM; 6 days) enhances the cytotoxicity mediated by gemcitabine.
PKI-166 hydrochloride is a potent, selective and orally active EGFR tyrosine kinase inhibitor, with an IC50 of 0.7 nM.
体内研究：
PKI-166 hydrochloride (100 mg/kg; p.o.; daily; for 29 days) inhibits of pancreatic cancer growth.Animal Model:Male athymic nude mice with L3.6pl cells xenograft (8-12 weeks)
Dosage:100 mg/kg
Administration:Oral administration; daily; for 29 days
Result:Significantly decreased median tumor volume.
体外研究：
PKI-166 hydrochloride (0-0.5 μM; 1 hour; pretreatment) inhibits EGFR autophosphorylation in human pancreatic cancer cells.PKI-166 hydrochloride (0.03 μM; 6 days) enhances the cytotoxicity mediated by gemcitabine.
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