产品
编 号：F618914
分子式：C31H31N5O3
分子量：521.61
分子式：C31H31N5O3
分子量：521.61
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CAS No: 2250019-90-8
产品详情
生物活性：
Ned-K is a nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. Ned-K is effective at dampening simulated ischaemia and reperfusion (sIR)-induced Ca2+ oscillations in cardiomyocytes.
体内研究：
Injection of Ned-K causes a significant reduction in infarct size in mice. Ned-K (administered i.v. to mice 5 min before reperfusion) significantly decreases myocardial infarct size relative to area at risk.
体外研究：
Ned-K suppresses Ca2+ oscillations and dramatically protects cardiomyocytes from cell death in vitro after ischaemia and reoxygenation, preventing opening of the mitochondrial permeability transition pore.Ned-K (10 μM) almost completely eliminates [Ca2+]c oscillations, and Ned-K (0.1 μM) is effective at suppressing [Ca2+]c levels.
Ned-K is a nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. Ned-K is effective at dampening simulated ischaemia and reperfusion (sIR)-induced Ca2+ oscillations in cardiomyocytes.
体内研究：
Injection of Ned-K causes a significant reduction in infarct size in mice. Ned-K (administered i.v. to mice 5 min before reperfusion) significantly decreases myocardial infarct size relative to area at risk.
体外研究：
Ned-K suppresses Ca2+ oscillations and dramatically protects cardiomyocytes from cell death in vitro after ischaemia and reoxygenation, preventing opening of the mitochondrial permeability transition pore.Ned-K (10 μM) almost completely eliminates [Ca2+]c oscillations, and Ned-K (0.1 μM) is effective at suppressing [Ca2+]c levels.
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