产品
编 号：F618878
分子式：C18H17F2N3O3
分子量：361.34
分子式：C18H17F2N3O3
分子量：361.34
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
10mg
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询价
结构图
CAS No: 2253947-47-4
产品详情
生物活性：
BMS-986235 (LAR-1219) is a selective, orally active formyl peptide receptor 2 (FPR2) agonist, with EC50s of 0.41 nM and 3.4 nM for hFPR2 and mFPR2, respectively. BMS-986235 has potential for the prevention of heart failure.
体内研究：
BMS-986235 (LAR-1219) (0.3 mg/kg；口服；每日一次，持续 24 天) 可减轻小鼠左前降支 (LAD) 后的左心室和整体心脏重塑。 BMS-986235 (1 mg/kg；po) 处理显示 Cmax、T1/2、AUC0-inf，和生物利用度 (BA) 值分别为 160 nmol/L、0.68 小时、120 nmol/L?h 和 24%。Animal Model:Male C57BL/6 mice
Dosage:0.3 mg/kg
Administration:P.o.; daily for 24 days
Result:Left ventricle (LV) chamber remodeling is attenuated after myocardial infarction (MI). Reduced infarct length by 39% relative to vehicle.
Animal Model:Male mice (BALB/cCrSlc)
Dosage:1 mg/kg
Administration:P.o. (Pharmacokinetic Analysis)
Result:The Cmax, T1/2, AUC0-inf, and bioavailability (BA) values were 160 nmol/L, 0.68 hours, 120 nmol/L?h, and 24%, respectively.
体外研究：
BMS-986235 (LAR-1219) 抑制中性粒细胞趋化作用并刺激巨噬细胞吞噬作用，这是促进炎症消退的关键终点。
BMS-986235 (LAR-1219) is a selective, orally active formyl peptide receptor 2 (FPR2) agonist, with EC50s of 0.41 nM and 3.4 nM for hFPR2 and mFPR2, respectively. BMS-986235 has potential for the prevention of heart failure.
体内研究：
BMS-986235 (LAR-1219) (0.3 mg/kg；口服；每日一次，持续 24 天) 可减轻小鼠左前降支 (LAD) 后的左心室和整体心脏重塑。 BMS-986235 (1 mg/kg；po) 处理显示 Cmax、T1/2、AUC0-inf，和生物利用度 (BA) 值分别为 160 nmol/L、0.68 小时、120 nmol/L?h 和 24%。Animal Model:Male C57BL/6 mice
Dosage:0.3 mg/kg
Administration:P.o.; daily for 24 days
Result:Left ventricle (LV) chamber remodeling is attenuated after myocardial infarction (MI). Reduced infarct length by 39% relative to vehicle.
Animal Model:Male mice (BALB/cCrSlc)
Dosage:1 mg/kg
Administration:P.o. (Pharmacokinetic Analysis)
Result:The Cmax, T1/2, AUC0-inf, and bioavailability (BA) values were 160 nmol/L, 0.68 hours, 120 nmol/L?h, and 24%, respectively.
体外研究：
BMS-986235 (LAR-1219) 抑制中性粒细胞趋化作用并刺激巨噬细胞吞噬作用，这是促进炎症消退的关键终点。
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