产品
编 号：F618764
分子式：C23H25NO5S
分子量：427.51
分子式：C23H25NO5S
分子量：427.51
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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结构图
CAS No: 2305757-96-2
产品详情
生物活性：
VII-31 is a potent NEDDylation pathway activator to inhibit the tumor progression in vitro and in vivo. VII-31 induces apoptosis via intrinsic and extrinsic pathways.
体内研究：
VII-31 inhibits the tumor progression in vivo, while showing no obvious toxicity to mice.Animal Model:Mice bearing MGC803 xenograft tumors
Dosage:50, 100, 150 mg/kg
Administration:Subcutaneous injection; daily for 28 days
Result:The mice had a much smaller tumor compared with vehicle control. The tumor volumes of middle/high dose treated mice at certain time points were evidently decreased comparing with untreated group.
体外研究：
VII-31 (100 nM, 200 nM; 48 hours) inhibits the cell viability of gastric cell line MGC803 with an IC50 of 0.09±0.01 μM. VII-31 also inhibits the cell viability ofMCF-7 and PC-3 with IC50s of 0.10±0.006 and 1.15±0.28μM , respectively.VII-31 (50-150 nM; 24 hours) arrests MGC803 cells cycle in G2/M phase.VII-31 (50-150 nM; 48 hours) induces apoptosis via intrinsic and extrinsic pathways.VII-31 (50-150 nM; 24 hours) activates NEDDylation in MGC803 cells.VII-31 (50-150 nM; 48 hours) up-regulates pro-apoptotic proteins FADD, Fasl, PIDD, Bax, Bad; while down-regulates anti-apoptotic proteins Bcl-xL, Bcl-2, XIAP, c-IAP1.
VII-31 is a potent NEDDylation pathway activator to inhibit the tumor progression in vitro and in vivo. VII-31 induces apoptosis via intrinsic and extrinsic pathways.
体内研究：
VII-31 inhibits the tumor progression in vivo, while showing no obvious toxicity to mice.Animal Model:Mice bearing MGC803 xenograft tumors
Dosage:50, 100, 150 mg/kg
Administration:Subcutaneous injection; daily for 28 days
Result:The mice had a much smaller tumor compared with vehicle control. The tumor volumes of middle/high dose treated mice at certain time points were evidently decreased comparing with untreated group.
体外研究：
VII-31 (100 nM, 200 nM; 48 hours) inhibits the cell viability of gastric cell line MGC803 with an IC50 of 0.09±0.01 μM. VII-31 also inhibits the cell viability ofMCF-7 and PC-3 with IC50s of 0.10±0.006 and 1.15±0.28μM , respectively.VII-31 (50-150 nM; 24 hours) arrests MGC803 cells cycle in G2/M phase.VII-31 (50-150 nM; 48 hours) induces apoptosis via intrinsic and extrinsic pathways.VII-31 (50-150 nM; 24 hours) activates NEDDylation in MGC803 cells.VII-31 (50-150 nM; 48 hours) up-regulates pro-apoptotic proteins FADD, Fasl, PIDD, Bax, Bad; while down-regulates anti-apoptotic proteins Bcl-xL, Bcl-2, XIAP, c-IAP1.
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