产品
编 号：F618757
分子式：C14H16ClNO
分子量：249.74
分子式：C14H16ClNO
分子量：249.74
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
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10mg
询价
询价
25mg
询价
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50mg
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询价
结构图
CAS No: 2306195-65-1
产品详情
生物活性：
BA-53038B is a HBV core protein allosteric modulator (CpAM), binding to the HAP pocket and modulating HBV capsid assembly. BA-53038B has antiviral activity for hepatitis B virus (HBV) with an EC50 value of 3.32 μM. BA-53038B can be used for the research of chronic hepatitis B.
体外研究：
BA-53038B has antiviral activity for HBV with an EC50 value of 3.32 μM.BA-53038B has cytotoxicity with CC50 value of >100 μM.BA-53038B (5 μM; 48 h) induces the capsid/nucleocapsid mobility shift and reduced the amount of hypophosphorylated core protein.BA-53038B (0-20 μM; 2 or 6 days) inhibits HBV nucleocapsid assembly.BA-53038B (5 μM; 2 days) inhibits pgRNA encapsidation and consequentially reduces the amount of DNA-containing capsids and hypophosphorylated core protein.BA-53038B (2 μM; 6 h) modulates HBV capsid assembly by binding to the HAP pocket.BA-53038B has resistant effect with an EC50 value of >10 μM on HBV capsid (HepG2 cells transiently transfected pHBV1.3/core-V124W).
BA-53038B is a HBV core protein allosteric modulator (CpAM), binding to the HAP pocket and modulating HBV capsid assembly. BA-53038B has antiviral activity for hepatitis B virus (HBV) with an EC50 value of 3.32 μM. BA-53038B can be used for the research of chronic hepatitis B.
体外研究：
BA-53038B has antiviral activity for HBV with an EC50 value of 3.32 μM.BA-53038B has cytotoxicity with CC50 value of >100 μM.BA-53038B (5 μM; 48 h) induces the capsid/nucleocapsid mobility shift and reduced the amount of hypophosphorylated core protein.BA-53038B (0-20 μM; 2 or 6 days) inhibits HBV nucleocapsid assembly.BA-53038B (5 μM; 2 days) inhibits pgRNA encapsidation and consequentially reduces the amount of DNA-containing capsids and hypophosphorylated core protein.BA-53038B (2 μM; 6 h) modulates HBV capsid assembly by binding to the HAP pocket.BA-53038B has resistant effect with an EC50 value of >10 μM on HBV capsid (HepG2 cells transiently transfected pHBV1.3/core-V124W).
产品资料
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