产品
编 号：F618701
分子式：C43H43ClN10O7S
分子量：879.38
分子式：C43H43ClN10O7S
分子量：879.38
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结构图
CAS No: 2334525-50-5
产品详情
生物活性：
TD-428 is a PROTAC connected by ligands for Cereblon and BRD4. TD-428 is a highly specific BRD4 degrader with a DC50?of?0.32?nM. TD-428 is a BET PROTAC, which comprises TD-106 (a CRBN ligand) linked to JQ1 (a BET inhibitor). TD-428 efficiently induce BET protein degradation.
体外研究：
TD-428, which comprises TD-106 linked to a BET inhibitor, JQ1 efficiently induce BET protein degradation in the prostate cancer cell line 22Rv1.TD-428 (0.01-10,000 nM; 72?hours) inhibits the proliferation of 22RV1 cells with a CC50?of??20.1?nM.TD-428 (1 nM-10?μM; 12?hours) induces the degradation of BRD4, IKZF1, and IKZF3 proteins.
TD-428 is a PROTAC connected by ligands for Cereblon and BRD4. TD-428 is a highly specific BRD4 degrader with a DC50?of?0.32?nM. TD-428 is a BET PROTAC, which comprises TD-106 (a CRBN ligand) linked to JQ1 (a BET inhibitor). TD-428 efficiently induce BET protein degradation.
体外研究：
TD-428, which comprises TD-106 linked to a BET inhibitor, JQ1 efficiently induce BET protein degradation in the prostate cancer cell line 22Rv1.TD-428 (0.01-10,000 nM; 72?hours) inhibits the proliferation of 22RV1 cells with a CC50?of??20.1?nM.TD-428 (1 nM-10?μM; 12?hours) induces the degradation of BRD4, IKZF1, and IKZF3 proteins.
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