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编 号:F618687
分子式:C25H27Cl2N3O
分子量:456.41
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生物活性:
JMS-17-2 hydrochloride is a potent and selective CX3CR1 antagonist with an IC50 of 0.32 nM. JMS-17-2 hydrochloride impairs metastatic seeding and colonization of breast cancer cells.

体内研究:
JMS-17-2 (10 mg/kg; aministered i.p.; twice a day for three weeks) causes a dramatic reduction of tumors in both skeleton and visceral organs in SCID mice.Animal Model:SCID mice (~25g) with MDA-231 xenograft
Dosage:10 mg/kg
Administration:Aministered i.p.; twice a day for three weeks
Result:Caused a dramatic reduction of tumors in both skeleton and visceral organs.
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