产品
编 号：F618435
分子式：C18H16Cl2N4O2
分子量：391.25
分子式：C18H16Cl2N4O2
分子量：391.25
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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结构图
CAS No: 2369751-30-2
产品详情
生物活性：
G150 is a highly selective human cyclic GMP-AMP synthase (h-cGAS) inhibitor with an IC50 of 10.2 nM. G150 represses dsDNA-triggered interferon expression, and G150 can be used for the research of inflammatory.
体外研究：
G150 (0.1-100 μM; 1 h) affects IFNB1 and CXCL10 expression in human THP1 cells and primary human macrophages.G150 (5-10 μM; 1 h) affects dsDNA sensing in THP1 cells and primary human macrophages.G150 (0.1-100 μM; 1 h) affects the NF-κB pathway activation in THP1-Dual cells.
G150 is a highly selective human cyclic GMP-AMP synthase (h-cGAS) inhibitor with an IC50 of 10.2 nM. G150 represses dsDNA-triggered interferon expression, and G150 can be used for the research of inflammatory.
体外研究：
G150 (0.1-100 μM; 1 h) affects IFNB1 and CXCL10 expression in human THP1 cells and primary human macrophages.G150 (5-10 μM; 1 h) affects dsDNA sensing in THP1 cells and primary human macrophages.G150 (0.1-100 μM; 1 h) affects the NF-κB pathway activation in THP1-Dual cells.
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