产品
编 号：F618433
分子式：C19H20ClFN4
分子量：358.84
分子式：C19H20ClFN4
分子量：358.84
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 2369979-68-8
产品详情
生物活性：
JHU37160 is a potent and brain-penetrant DREADD agonist, with EC50s of 18.5?nM and 0.2?nM for hM3Dq and hM4Di DREADDs in HEK-293 cells, respectively. JHU37160 exhibits selective [3H]Clozapine displacement from DREADDs and not from other Clozapine-binding sites in mice brain tissue.
体内研究：
JHU37160 (0.1 mg/kg; i.p.) exhibits high DREADD occupancy in mice and rats.JHU37160 (0.01-1 mg/kg; i.p.) selectively inhibits locomotor activity in D1-hM3Dq and D1-hM4Di mice without any significant locomotor effects observed in WT mice.
体外研究：
JHU37160 displays high DREADD affinity, with Kis of 1.9?nM and 3.6?nM for hM3Dq and hM4Di expressed in mouse brain sections.JHU37160 (1-1000 nM) selectively displaces [3H]Clozapine displacement from DREADDs and not from other Clozapine-binding sites.
JHU37160 is a potent and brain-penetrant DREADD agonist, with EC50s of 18.5?nM and 0.2?nM for hM3Dq and hM4Di DREADDs in HEK-293 cells, respectively. JHU37160 exhibits selective [3H]Clozapine displacement from DREADDs and not from other Clozapine-binding sites in mice brain tissue.
体内研究：
JHU37160 (0.1 mg/kg; i.p.) exhibits high DREADD occupancy in mice and rats.JHU37160 (0.01-1 mg/kg; i.p.) selectively inhibits locomotor activity in D1-hM3Dq and D1-hM4Di mice without any significant locomotor effects observed in WT mice.
体外研究：
JHU37160 displays high DREADD affinity, with Kis of 1.9?nM and 3.6?nM for hM3Dq and hM4Di expressed in mouse brain sections.JHU37160 (1-1000 nM) selectively displaces [3H]Clozapine displacement from DREADDs and not from other Clozapine-binding sites.
产品资料
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