产品
编 号：F618410
分子式：C31H28N6O2
分子量：516.59
分子式：C31H28N6O2
分子量：516.59
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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结构图
CAS No: 2375482-51-0
产品详情
生物活性：
BI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) by structure-based agent design with nanomolar affinity. BI-2852 is mechanistically distinct from covalent KRASG12C inhibitor (binds to switch II pocket) and binds ten-fold more strongly to active KRASG12D versus KRASwt (740 nM vs 7.5 μM). BI-2852 blocks GEF, GAP, and effector interactions with KRAS, leading to inhibition of downstream signaling and an antiproliferative effect in KRAS mutant cells.
体外研究：
BI-2852 (化合物 1) (10 nM-10 μM；2 小时) 在 EC50 5.8 μM 和 6.7 μM 软琼脂和低血清中表现出剂量依赖性 pERK 调节和抗增殖作用 NCI-H358 细胞条件。
BI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) by structure-based agent design with nanomolar affinity. BI-2852 is mechanistically distinct from covalent KRASG12C inhibitor (binds to switch II pocket) and binds ten-fold more strongly to active KRASG12D versus KRASwt (740 nM vs 7.5 μM). BI-2852 blocks GEF, GAP, and effector interactions with KRAS, leading to inhibition of downstream signaling and an antiproliferative effect in KRAS mutant cells.
体外研究：
BI-2852 (化合物 1) (10 nM-10 μM；2 小时) 在 EC50 5.8 μM 和 6.7 μM 软琼脂和低血清中表现出剂量依赖性 pERK 调节和抗增殖作用 NCI-H358 细胞条件。
产品资料
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