产品
编 号：F618372
分子式：C45H45BrN6O10S
分子量：941.84
分子式：C45H45BrN6O10S
分子量：941.84
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
结构图
CAS No: 2378801-85-3
产品详情
生物活性：
PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC based on Cereblon ligand, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 μM; DC50, 3.0 μM) and Mcl-1 (IC50, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1 (Blue: CRBN ligand, Black: linker；Pink: Mcl-1/Bcl-2 inhibitor, Nap-1).
体外研究：
PROTAC Bcl2 degrader-1 (10 μM, 24 h) 时间和浓度依赖的选择性耗竭 Hela 细胞中的 Mcl-1 或 Bcl-2 蛋白。
PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC based on Cereblon ligand, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 μM; DC50, 3.0 μM) and Mcl-1 (IC50, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1 (Blue: CRBN ligand, Black: linker；Pink: Mcl-1/Bcl-2 inhibitor, Nap-1).
体外研究：
PROTAC Bcl2 degrader-1 (10 μM, 24 h) 时间和浓度依赖的选择性耗竭 Hela 细胞中的 Mcl-1 或 Bcl-2 蛋白。
产品资料
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