产品
编 号：F618338
分子式：C15H9BrO5
分子量：349.13
分子式：C15H9BrO5
分子量：349.13
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CAS No: 2387510-84-9
产品详情
生物活性：
AM12 inhibits Lanthanide-evoked TRPC5 activity with an IC50 of 0.28 μM.
体外研究：
AM12 also inhibits TRPC5 activity evoked by the agonist (-)-Englerin A. AM12 also inhibits TRPC4 channels similarly. AM12 inhibits TRPC5 and TRPC4 channels via a site accessible from the extracellular face of the membrane, acting directly on either the channel or a site closely associated with it. AM12 also inhibits Ca2+ entry evoked by Gd3+. AM12 inhibits the Gd3+-evoked Ca2+ signal with an IC50 of 0.28 μM.AM12 is slightly more potent than the natural product Galangin as an inhibitor of the Gd3+-evoked signal.
AM12 inhibits Lanthanide-evoked TRPC5 activity with an IC50 of 0.28 μM.
体外研究：
AM12 also inhibits TRPC5 activity evoked by the agonist (-)-Englerin A. AM12 also inhibits TRPC4 channels similarly. AM12 inhibits TRPC5 and TRPC4 channels via a site accessible from the extracellular face of the membrane, acting directly on either the channel or a site closely associated with it. AM12 also inhibits Ca2+ entry evoked by Gd3+. AM12 inhibits the Gd3+-evoked Ca2+ signal with an IC50 of 0.28 μM.AM12 is slightly more potent than the natural product Galangin as an inhibitor of the Gd3+-evoked signal.
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