产品
编 号：F618337
分子式：C22H24Cl3FN4
分子量：469.81
分子式：C22H24Cl3FN4
分子量：469.81
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
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10mg
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25mg
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50mg
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结构图
CAS No: 2387510-87-2
产品详情
生物活性：
BI-9321 trihydrochloride is a potent, selective and cellular active nuclear receptor-binding SET domain 3 (NSD3)-PWWP1 domain antagonist with a Kd value of 166 nM. BI-9321 trihydrochloride is inactive against NSD2-PWWP1 and NSD3-PWWP2. BI-9321 trihydrochloride specifically disrupts histone interactions of the NSD3-PWWP1 domain with an IC50 of 1.2 μM in U2OS cells.
体外研究：
BI-9321 trihydrochloride 靶向 PWWP1 结构域的甲基-赖氨酸结合位点，在 1 μM 时具有亚微摩尔体外活性和细胞靶标结合。作为单一药剂，BI-9321 trihydrochloride 下调 Myc 信使 RNA 表达并减少 MOLM-13 细胞的增殖。
BI-9321 trihydrochloride is a potent, selective and cellular active nuclear receptor-binding SET domain 3 (NSD3)-PWWP1 domain antagonist with a Kd value of 166 nM. BI-9321 trihydrochloride is inactive against NSD2-PWWP1 and NSD3-PWWP2. BI-9321 trihydrochloride specifically disrupts histone interactions of the NSD3-PWWP1 domain with an IC50 of 1.2 μM in U2OS cells.
体外研究：
BI-9321 trihydrochloride 靶向 PWWP1 结构域的甲基-赖氨酸结合位点，在 1 μM 时具有亚微摩尔体外活性和细胞靶标结合。作为单一药剂，BI-9321 trihydrochloride 下调 Myc 信使 RNA 表达并减少 MOLM-13 细胞的增殖。
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