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编 号:F618237
分子式:C16H11F3N2O4
分子量:352.26
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10mM*1mL in DMSO
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1mg
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5mg
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10mg
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25mg
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生物活性:
yGsy2p-IN-1 is a potent inhibitor for yeast glycogen synthase 2 (yGsy2p). yGsy2p-IN-1 is a competitive human glycogen synthase 1 (hGYS1) inhibitor with an IC50 of 2.75 μM and a Ki of 1.31 μM for wild-type hGYS1. yGsy2p-IN-H23 a pyrazole inhibitor, is used for glycogen storage diseases (GSDs).

体外研究:
yGsy2p-IN-1 (compound 23; 0.1, 1, 10, 100, 1000 μM) has IC50s of 7.89 μM and 33.6 μM for yGsy2p-WT and yGsy2p-Y513L. yGsy2p-IN-1 (100 μM) exhibits almost complete inhibition of synthase activity in both HEK293-PTG and Rat-1 cell lysates.
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