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编 号：F618226
分子式：C15H20N2O10
分子量：388.33
分子式：C15H20N2O10
分子量：388.33
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CAS No: 2415659-01-5
产品详情
生物活性：
Nicotinamide riboside malate, an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3. Nicotinamide riboside malate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside malate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease.
体内研究：
Chronic Nicotinamide riboside malate (p.o.; 400 mg/kg/day; for 16 weeks) supplementation increases plasma and intracellular NAD+ content in a tissue-specific manner.Animal Model:10-week-old C57Bl/6J mice
Dosage:400 mg/kg
Administration:PO; daily; for 16 weeks
Result:Increased plasma and intracellular NAD+ content in a tissue-specific manner.
体外研究：
Nicotinamide riboside malate (0.5 mM; 24 hours) reduces the acetylation status of Ndufa9 and SOD2.Nicotinamide riboside malate increases intracellular and mitochondrial NAD+ content in C2C12, Hepa1.6, and HEK293 cells in a concentration-dependent manner at concentrations ranging from 1-1000 μM.Nicotinamide riboside malate boosts NAD to restore antiviral poly(ADP-ribose) polymerase (PARP) functions to support innate immunity for coronavirus (CoVs), a cause of COVID-19.
Nicotinamide riboside malate, an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3. Nicotinamide riboside malate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside malate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease.
体内研究：
Chronic Nicotinamide riboside malate (p.o.; 400 mg/kg/day; for 16 weeks) supplementation increases plasma and intracellular NAD+ content in a tissue-specific manner.Animal Model:10-week-old C57Bl/6J mice
Dosage:400 mg/kg
Administration:PO; daily; for 16 weeks
Result:Increased plasma and intracellular NAD+ content in a tissue-specific manner.
体外研究：
Nicotinamide riboside malate (0.5 mM; 24 hours) reduces the acetylation status of Ndufa9 and SOD2.Nicotinamide riboside malate increases intracellular and mitochondrial NAD+ content in C2C12, Hepa1.6, and HEK293 cells in a concentration-dependent manner at concentrations ranging from 1-1000 μM.Nicotinamide riboside malate boosts NAD to restore antiviral poly(ADP-ribose) polymerase (PARP) functions to support innate immunity for coronavirus (CoVs), a cause of COVID-19.
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