产品
编 号：F618186
分子式：C17H20BrN3O3S2
分子量：458.39
分子式：C17H20BrN3O3S2
分子量：458.39
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
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10mg
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询价
结构图
CAS No: 2437475-16-4
产品详情
生物活性：
T6167923 is a selective inhibitor of MyD88-dependent signaling pathways. T6167923 directly binds to Toll/IL1 receptor (TIR) domain of MyD88 and disrupts MyD88 homodimeric formation. T6167923 inhibits NF-κB driven Staphylococcus enterotoxin AP (SEAP) activity, and improves anti-inflammatory activity with IC50s of 2.7 ?μM, 2.9 μM, 2.66 μM and 2.66 μM for IFN-γ, IL-1β, IL-6 and TNF-α, respectively.
体内研究：
T6167923 (0.17 and 1 mg; i.p. once) survives the mice from intoxication with SEB and LPS injection.Animal Model:16-20 week-old BALB/c mice with LPS potentiation model
Dosage:0.17 and 1 mg
Administration:Intraperitoneal injection; 0.17 and 1 mg once
Result:Dose-dependently showed a therapeutic efficacy against SEB intoxication.
体外研究：
T6167923 (0-500 μM; 20 h) inhibits the pro-inflammatory cytokine response of staphylococcal enterotoxin B (SEB) in peripheral blood mono nuclear cells.T6167923 (10-500 μM; 2 h) inhibits secreted alkaline phosphatase response (SEAP) expression in HEK 293T cells.T6167923 (100 μM; 16 h) binds to TIR protein and reduced the inhibitory effect onMyD88-signaling.T6167923 (1-500 μM; 13 h) inhibits full-length MyD88 homodimeric formation.
T6167923 is a selective inhibitor of MyD88-dependent signaling pathways. T6167923 directly binds to Toll/IL1 receptor (TIR) domain of MyD88 and disrupts MyD88 homodimeric formation. T6167923 inhibits NF-κB driven Staphylococcus enterotoxin AP (SEAP) activity, and improves anti-inflammatory activity with IC50s of 2.7 ?μM, 2.9 μM, 2.66 μM and 2.66 μM for IFN-γ, IL-1β, IL-6 and TNF-α, respectively.
体内研究：
T6167923 (0.17 and 1 mg; i.p. once) survives the mice from intoxication with SEB and LPS injection.Animal Model:16-20 week-old BALB/c mice with LPS potentiation model
Dosage:0.17 and 1 mg
Administration:Intraperitoneal injection; 0.17 and 1 mg once
Result:Dose-dependently showed a therapeutic efficacy against SEB intoxication.
体外研究：
T6167923 (0-500 μM; 20 h) inhibits the pro-inflammatory cytokine response of staphylococcal enterotoxin B (SEB) in peripheral blood mono nuclear cells.T6167923 (10-500 μM; 2 h) inhibits secreted alkaline phosphatase response (SEAP) expression in HEK 293T cells.T6167923 (100 μM; 16 h) binds to TIR protein and reduced the inhibitory effect onMyD88-signaling.T6167923 (1-500 μM; 13 h) inhibits full-length MyD88 homodimeric formation.
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