产品
编 号：F618130
分子式：C25H19F2N5O2
分子量：459.45
分子式：C25H19F2N5O2
分子量：459.45
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
结构图
CAS No: 2471967-92-5
产品详情
生物活性：
BAY-899 is an orally active and selective luteinizing hormone receptor (LH-R) antagonist with IC50s of 185 nM and 46nM for hLH (human LH) and rLH (rat LH), respectively. BAY-899 can reduce sex hormone levels.
体内研究：
BAY-899 (oral; 12.5 mg/kg/day; for 8 days) shows an efficiency to reduce serum estradiol levels in intact female rats.BAY-899 (iv of 0.5 mg/kg or po of 2 mg/kg) has a t1/2 of 11 hours and 12 hours for iv and po. And the Cmax is 0.97 kg/L and 0.24 kg/L for iv and po. Animal Model:Intact female rats
Dosage:12.5 mg/kg
Administration:Oral; for 8 days
Result:Showed an efficiency to reduce serum estradiol levels.
Animal Model:Female and male Wistar rats
Dosage:0.5 mg/kg of iv or 2 mg/kg of po
Administration:Iv or po
Result:Has t1/2s of 11 hours and 12 hours for iv and po. And the Cmaxs are 0.97 kg/L and 0.24 kg/L for iv and po.
BAY-899 is an orally active and selective luteinizing hormone receptor (LH-R) antagonist with IC50s of 185 nM and 46nM for hLH (human LH) and rLH (rat LH), respectively. BAY-899 can reduce sex hormone levels.
体内研究：
BAY-899 (oral; 12.5 mg/kg/day; for 8 days) shows an efficiency to reduce serum estradiol levels in intact female rats.BAY-899 (iv of 0.5 mg/kg or po of 2 mg/kg) has a t1/2 of 11 hours and 12 hours for iv and po. And the Cmax is 0.97 kg/L and 0.24 kg/L for iv and po. Animal Model:Intact female rats
Dosage:12.5 mg/kg
Administration:Oral; for 8 days
Result:Showed an efficiency to reduce serum estradiol levels.
Animal Model:Female and male Wistar rats
Dosage:0.5 mg/kg of iv or 2 mg/kg of po
Administration:Iv or po
Result:Has t1/2s of 11 hours and 12 hours for iv and po. And the Cmaxs are 0.97 kg/L and 0.24 kg/L for iv and po.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备