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编 号：F617800
分子式：C14H23N3O3S
分子量：313.42
分子式：C14H23N3O3S
分子量：313.42
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CAS No: 101526-83-4
产品详情
生物活性：
Sematilide (CK-1752) is a selective IKr channel blocker. Sematilide causes a concentration-dependent inhibition of the delayed rectifier K+ current (IC50=25 μM). Sematilide is a class III antiarrhythmic agent.
体内研究：
Sematilide (0.3-1.0 mg/kg, intravenously i.v.) is effective in a canine model of arrhythmia.Animal Model:Mongrel dogs of either sex (10-18 kg body weight)
Dosage:0.3, 1, 3, and 10 mg/kg
Administration:I.v. infusions
Result:Demonstrated antiarrhythmic effects at 0.3 and 3.0 mg/kg.
体外研究：
Application of 10, 30, 100 and 300 μM Sematilide causes a concentration-dependent inhibition of the delayed rectifier K+ current (IC50=25 μM).
Sematilide (CK-1752) is a selective IKr channel blocker. Sematilide causes a concentration-dependent inhibition of the delayed rectifier K+ current (IC50=25 μM). Sematilide is a class III antiarrhythmic agent.
体内研究：
Sematilide (0.3-1.0 mg/kg, intravenously i.v.) is effective in a canine model of arrhythmia.Animal Model:Mongrel dogs of either sex (10-18 kg body weight)
Dosage:0.3, 1, 3, and 10 mg/kg
Administration:I.v. infusions
Result:Demonstrated antiarrhythmic effects at 0.3 and 3.0 mg/kg.
体外研究：
Application of 10, 30, 100 and 300 μM Sematilide causes a concentration-dependent inhibition of the delayed rectifier K+ current (IC50=25 μM).
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