产品
编 号：F617459
分子式：C15H17ClN2O2S
分子量：324.83
分子式：C15H17ClN2O2S
分子量：324.83
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CAS No: 110448-31-2
产品详情
生物活性：
ML-9 (Free Base) is a selective and potent inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK) and stromal interaction molecule 1 (STIM1) activity. ML-9 (Free Base) inhibits inhibits MLCK, PKA and PKC activity with Ki values of 4, 32 and 54?μM, respectively. ML-9 (Free Base) induces autophagy by stimulating autophagosome formation and inhibiting their degradation.
体外研究：
ML9 (Free Base) (0-100?μM; 0-24?hours) has no reduction in cardiomyocyte viability,50-100?μM significantly induces cell death.ML9 (Free Base) (50?μM; 1-4?hours) significantly increases cleaved?caspase-3?levels,decreased STIM1 protein levels by about 42%.
ML-9 (Free Base) is a selective and potent inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK) and stromal interaction molecule 1 (STIM1) activity. ML-9 (Free Base) inhibits inhibits MLCK, PKA and PKC activity with Ki values of 4, 32 and 54?μM, respectively. ML-9 (Free Base) induces autophagy by stimulating autophagosome formation and inhibiting their degradation.
体外研究：
ML9 (Free Base) (0-100?μM; 0-24?hours) has no reduction in cardiomyocyte viability,50-100?μM significantly induces cell death.ML9 (Free Base) (50?μM; 1-4?hours) significantly increases cleaved?caspase-3?levels,decreased STIM1 protein levels by about 42%.
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