产品
编 号：F065808
分子式：C18H21FN4O4
分子量：376.38
分子式：C18H21FN4O4
分子量：376.38
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CAS No: 119354-43-7
产品详情
生物活性：
Antofloxacin is a well tolerate, orally active and broad-spectrum 8-amino-fluoroquinolone with potent antibacterial activities. Antofloxacin shows superior antibacterial activity against gyrA mutation-positive H. pylori strains, especially in Asn87- mutated strains, compared to levofloxacin. Antofloxacin is a weak, reversible inhibitor of CYP1A2 for the research of infections caused by a diverse group of bacterial species.
体内研究：
Antofloxacin (2.5~160 mg/kg; s.c.; 24 hours) penetration ratio ranges from 1.22 to 1.54 for the total drug concentrations and is independent of the dose levels.Antofloxacin increases the plasma theophylline concentration, partly by acting as a mechanism based inhibitor of CYP1A2. Antofloxacin inhibits the formation of the three metabolites of theophylline was time-, concentration- and NADPH-dependent, which is characteristic of mechanism-based inhibition.Animal Model:Mice
Dosage:2.5~160 mg/kg (Pharmacokinetic Analysis)
Administration:S.c.; 24 hours
Result:Penetration ratio ranged from 1.22 to 1.54 for the total drug concentrations and was independent of the dose levels.
Antofloxacin is a well tolerate, orally active and broad-spectrum 8-amino-fluoroquinolone with potent antibacterial activities. Antofloxacin shows superior antibacterial activity against gyrA mutation-positive H. pylori strains, especially in Asn87- mutated strains, compared to levofloxacin. Antofloxacin is a weak, reversible inhibitor of CYP1A2 for the research of infections caused by a diverse group of bacterial species.
体内研究：
Antofloxacin (2.5~160 mg/kg; s.c.; 24 hours) penetration ratio ranges from 1.22 to 1.54 for the total drug concentrations and is independent of the dose levels.Antofloxacin increases the plasma theophylline concentration, partly by acting as a mechanism based inhibitor of CYP1A2. Antofloxacin inhibits the formation of the three metabolites of theophylline was time-, concentration- and NADPH-dependent, which is characteristic of mechanism-based inhibition.Animal Model:Mice
Dosage:2.5~160 mg/kg (Pharmacokinetic Analysis)
Administration:S.c.; 24 hours
Result:Penetration ratio ranged from 1.22 to 1.54 for the total drug concentrations and was independent of the dose levels.
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