产品
编 号：F065779
分子式：C15H21N5O13P2
分子量：541.3
分子式：C15H21N5O13P2
分子量：541.3
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CAS No: 119340-53-3
产品详情
生物活性：
Cyclic ADP-ribose (cADPR) is a potent second messenger for calcium mobilization that is synthesized from NAD+ by an ADP-ribosyl cyclase. Cyclic ADP-ribose increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels.
体内研究：
cADPR (100 μM; push-pull type of brain microperfusion) elevats OT concentrations in ordinate or subordinate mice.
体外研究：
cADPR (20 nM) elicits a large rapid Ca2+ release in sea urchin eggs homogenates.cADPR (100 μM; 10 min) induces a sustained elevation of intracellular calcium concentration in a subset (64%) of cultured astrocytes.cADPR (100 μM) and heat (35-38.5 ℃) stimulates oxytocin OT release from the isolated hypothalami of male mice in culture.
Cyclic ADP-ribose (cADPR) is a potent second messenger for calcium mobilization that is synthesized from NAD+ by an ADP-ribosyl cyclase. Cyclic ADP-ribose increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels.
体内研究：
cADPR (100 μM; push-pull type of brain microperfusion) elevats OT concentrations in ordinate or subordinate mice.
体外研究：
cADPR (20 nM) elicits a large rapid Ca2+ release in sea urchin eggs homogenates.cADPR (100 μM; 10 min) induces a sustained elevation of intracellular calcium concentration in a subset (64%) of cultured astrocytes.cADPR (100 μM) and heat (35-38.5 ℃) stimulates oxytocin OT release from the isolated hypothalami of male mice in culture.
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