产品
编 号：F615966
分子式：C122H196N40O39
分子量：2847.11
分子式：C122H196N40O39
分子量：2847.11
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CAS No: 151804-79-4
产品详情
生物活性：
AC 253, an amylin antagonist, inhibits 125I-adrenomedullin binding, with an IC50 of 25 nM.
体外研究：
AC 253 (5-20 μM) antagonizes adrenomedullin-stimulated cAMP production at micromolar concentrations.AC 253 (5-10 μM) blocks increases in intracellular Ca2+, activation of protein kinase A, MAPK, Akt, cFos, and cell death, which occur upon AMY3 activation with hAmylin, Aβ1-42, or their co-application.AC 253 (10 nM) blocks Aβ1-42-induced electrophysiological effects.
AC 253, an amylin antagonist, inhibits 125I-adrenomedullin binding, with an IC50 of 25 nM.
体外研究：
AC 253 (5-20 μM) antagonizes adrenomedullin-stimulated cAMP production at micromolar concentrations.AC 253 (5-10 μM) blocks increases in intracellular Ca2+, activation of protein kinase A, MAPK, Akt, cFos, and cell death, which occur upon AMY3 activation with hAmylin, Aβ1-42, or their co-application.AC 253 (10 nM) blocks Aβ1-42-induced electrophysiological effects.
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