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编 号：F615787
分子式：C24H18FN5O2
分子量：427.43
分子式：C24H18FN5O2
分子量：427.43
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CAS No: 158876-65-4
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生物活性：
FR 167653 free base, an orally active and selective p38 MAPK inhibitor, is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MAPK activity. FR 167653 free base is effective in treating inflammation, relieving trauma and ischemia-reperfusion injury in vivo.
体内研究：
FR 167653 free base (32 mg/kg; i.h.; 24-48 hours) significantly decreases the extent of acute tubular necrosis.Animal Model:Inbred male Balbuc mice (aged 8 weeks)
Dosage:32 mg/kg
Administration:Subcutaneous injection; 24-48 hours
Result:The scores of acute tubular necrosis in FR-167653-treated mice were significantly lower in vehicle-treated mice at 24 and 48 h after ischaemiaureperfusion both in cortex and outer medulla.
FR 167653 free base, an orally active and selective p38 MAPK inhibitor, is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MAPK activity. FR 167653 free base is effective in treating inflammation, relieving trauma and ischemia-reperfusion injury in vivo.
体内研究：
FR 167653 free base (32 mg/kg; i.h.; 24-48 hours) significantly decreases the extent of acute tubular necrosis.Animal Model:Inbred male Balbuc mice (aged 8 weeks)
Dosage:32 mg/kg
Administration:Subcutaneous injection; 24-48 hours
Result:The scores of acute tubular necrosis in FR-167653-treated mice were significantly lower in vehicle-treated mice at 24 and 48 h after ischaemiaureperfusion both in cortex and outer medulla.
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