产品
编 号：F615039
分子式：C28H46O4
分子量：446.66
分子式：C28H46O4
分子量：446.66
产品类型
规格
价格
是否有货
1mg
询价
询价
结构图
CAS No: 182369-28-4
产品详情
生物活性：
CB1151 is a 20-epi analogue of 1,25 dihydroxyvitamin D3 (VD) with potent anti-tumor effects. CB1151 inhibits MCF-7 cell growth with an IC50 value of 0.82 nM.
体外研究：
CB1151 (0-100 nM; 5 days) inhibitsMCF-7 cells growth, this cell proliferation is accessed by [3H]-thymidine incorporation, exhibits an IC50 value of0.82 nM.CB1151 (0-100 nM; 40 hours) exhibits activation of the IP9-type VD response element with a EC50 of 1.2 nM,the activation ofIP9-type VD response elements shows a good correlation with inhibition ofproliferation than the activation ofDR3-type elements (EC50=3.2nM) in MCF-7 cells transfected with the CAT reporter. CB1151 shows a functional dissociation constant (Kdf) value of3.6 nM. The ligand concentration that provides 50% ofprotease-resistant VDR fragment is defined by Kdf, this is different from that of the traditional dissociation constant (Kd).
CB1151 is a 20-epi analogue of 1,25 dihydroxyvitamin D3 (VD) with potent anti-tumor effects. CB1151 inhibits MCF-7 cell growth with an IC50 value of 0.82 nM.
体外研究：
CB1151 (0-100 nM; 5 days) inhibitsMCF-7 cells growth, this cell proliferation is accessed by [3H]-thymidine incorporation, exhibits an IC50 value of0.82 nM.CB1151 (0-100 nM; 40 hours) exhibits activation of the IP9-type VD response element with a EC50 of 1.2 nM,the activation ofIP9-type VD response elements shows a good correlation with inhibition ofproliferation than the activation ofDR3-type elements (EC50=3.2nM) in MCF-7 cells transfected with the CAT reporter. CB1151 shows a functional dissociation constant (Kdf) value of3.6 nM. The ligand concentration that provides 50% ofprotease-resistant VDR fragment is defined by Kdf, this is different from that of the traditional dissociation constant (Kd).
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备