产品
编 号：F615017
分子式：C177H300N56O46S8
分子量：4205.17
分子式：C177H300N56O46S8
分子量：4205.17
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规格
价格
是否有货
结构图
CAS No: 183815-75-0
产品详情
生物活性：
OSK-1 is a potent Kv channel blocker with IC50s of of 0.6 nM, 5.4 nM, 0.014 nM for Kv1.1, Kv1.2 and Kv1.3, respectively. OSK1 is a moderate blocker of Ca2+-activated KCa3.1 channel with an IC50 of 225 nM. OSK-1 belongs to α-KTx3 toxins and is used as a immunosuppressive agent.
体内研究：
OSK1 is lethal in mice by intracerebroventricular injection, with a LD50 (50% lethal dose) value of 2 μg/kg.
体外研究：
OSK1 has no effect on KCa2.1, KCa2.2, KCa2.3 and KCa1.1 channels when in the micromolar concentration range, whereas it shows a moderate activity on KCa3.1 channel (also referred to as IK1 or SK4) with an IC50 value of 225 nM.
OSK-1 is a potent Kv channel blocker with IC50s of of 0.6 nM, 5.4 nM, 0.014 nM for Kv1.1, Kv1.2 and Kv1.3, respectively. OSK1 is a moderate blocker of Ca2+-activated KCa3.1 channel with an IC50 of 225 nM. OSK-1 belongs to α-KTx3 toxins and is used as a immunosuppressive agent.
体内研究：
OSK1 is lethal in mice by intracerebroventricular injection, with a LD50 (50% lethal dose) value of 2 μg/kg.
体外研究：
OSK1 has no effect on KCa2.1, KCa2.2, KCa2.3 and KCa1.1 channels when in the micromolar concentration range, whereas it shows a moderate activity on KCa3.1 channel (also referred to as IK1 or SK4) with an IC50 value of 225 nM.
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