产品
编 号:F065355
分子式:C35H35N5O4
分子量:589.68
产品类型
结构图
CAS No: 1192750-33-6
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产品详情
生物活性:
PE154 (Compound 13) is a potent fluorescent inhibitor of human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) (IC50s=280 pM and 16 nM, respectively). PE154 can label β-amyloid plaques in histochemical analysis.
体内研究:
PE154 (hippocampus injection; 0.2 μg per mouse; once) can stain the histochemical of cortical βamyloid plaques.Animal Model:13–20-month-old triple-transgenic mice harbouring three mutant genes (APPswe, PS-1 and tauP301L)
Dosage:0.2 μg per mouse
Administration:Hippocampus injection; 0.2 μg per mouse; once
Result:Showed the histochemical staining of cortical βamyloid plaques in triple-transgenic (TTG) mice.