产品
编 号:F614609
分子式:C31H32N4O4
分子量:524.61
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1mg
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5mg
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10mg
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生物活性:
LY377604 is a human β3-adrenergic receptor agonist with an EC50 of 2.4 nM and also a β1- and β2-adrenergic receptor antagonist.

体内研究:
Administration of LY377604 to male Long-Evans rats fed a caloric dense diet results in stimulation of lipid utilization. This is observed as a decrease in respiratory quotient and persists for about 4 h before returning to that measured from vehicle-treated rats.

体外研究:
LY377604 is a human β3-adrenergic receptor agonist with an EC50 of 2.4 nM and also a β1- and β2-adrenergic receptor antagonist. LY377604 causes a maximal increase in cyclic adenosine monophosphate (cAMP) levels, but does not stimulate cAMP accumulation in CHO cells transfected with either the human β1 adrenergic receptor or the human β2 adrenergic receptor.
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