产品
编 号:F614562
分子式:C11H12N2O7
分子量:284.22
产品类型
结构图
CAS No: 207613-14-7
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产品详情
生物活性:
Mal-amido-(CH2COOH)2, compound 7a, is a maleimidoethyl-containing intermediate for hydrophilic ADC linker.
体内研究:
ADC Linker
体外研究:
Mal-amido-(CH2COOH)2 is a intermediate for linker. Bivalent doxorubicin (DOX)-dipeptides (16a-c) are finally prepared and conjugated to the monoclonal antibody BR96. The dipeptides are cleaved by lysosomal proteases following internalization of the resulting immunoconjugates.