产品
编 号：F614415
分子式：C20H23BrN3O8P
分子量：544.29
分子式：C20H23BrN3O8P
分子量：544.29
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 217178-62-6
产品详情
生物活性：
Stampidine is a nucleoside reverse transcriptase inhibitor (NRTI) with potent and broad-spectrum anti-HIV activity. Stampidine inhibits the laboratory HIV-1 strain HTLVIIIB (B-envelope subtype) and primary clinical isolates with IC50s of 1 nM and 2 nM, respectively. Stampidine also inhibits NRTI-resistant primary clinical isolates and NNRTI-resistant clinical isolates with IC50s of 8.7 nM and 11.2 nM, respectively.
体内研究：
Stampidine (50-100 mg/kg; p.o.) exhibits potent antiretroviral activity in chronically feline immunodeficiency virus (FIV)-infected cats.Stampidine (100 mg/kg; p.o.) shows the average plasma Cmax, AUC, half-life (t1/2), and mean residence time (MRT) values of 15.4 μM, 23.1 μM?h, 108.6 min and 119.4 min, respectively, in dogs.Stampidine does not cause anemia, thrombocytopenia, neutropenia, or lymphopenia suggestive of hematologic toxicity, elevations of BUN or creatinine or electrolyte disturbances suggestive of renal toxicity or metabolic abnormalities, elevations of ALT, AST, Alk in adult beagle dogs.Animal Model:SPF male or female domestic cats (2.9- 6.2 kg), with chronically FIV-infected
Dosage:50 mg/kg, 100 mg/kg
Administration:Oral administration (oral bolus dose)
Result:Exhibited potent antiretroviral activity.
Animal Model:Male beagle dogs (10-12 kg)
Dosage:100 mg/kg (Pharmacokinetic Analysis)
Administration:Oral administration
Result:The estimated average plasma Cmax and AUC values were 15.4 μM and 23.1 μM·h, respectively. The average elimination half-life (t1/2) and mean residence time (MRT) were 108.6 min and 119.4 min, respectively.
体外研究：
Stampidine (7.8-1,000 μM; 24 hours) is not cytotoxic to genital tract epithelial cells.Stampidine has no effect on sperm motility in cervical mucus.
Stampidine is a nucleoside reverse transcriptase inhibitor (NRTI) with potent and broad-spectrum anti-HIV activity. Stampidine inhibits the laboratory HIV-1 strain HTLVIIIB (B-envelope subtype) and primary clinical isolates with IC50s of 1 nM and 2 nM, respectively. Stampidine also inhibits NRTI-resistant primary clinical isolates and NNRTI-resistant clinical isolates with IC50s of 8.7 nM and 11.2 nM, respectively.
体内研究：
Stampidine (50-100 mg/kg; p.o.) exhibits potent antiretroviral activity in chronically feline immunodeficiency virus (FIV)-infected cats.Stampidine (100 mg/kg; p.o.) shows the average plasma Cmax, AUC, half-life (t1/2), and mean residence time (MRT) values of 15.4 μM, 23.1 μM?h, 108.6 min and 119.4 min, respectively, in dogs.Stampidine does not cause anemia, thrombocytopenia, neutropenia, or lymphopenia suggestive of hematologic toxicity, elevations of BUN or creatinine or electrolyte disturbances suggestive of renal toxicity or metabolic abnormalities, elevations of ALT, AST, Alk in adult beagle dogs.Animal Model:SPF male or female domestic cats (2.9- 6.2 kg), with chronically FIV-infected
Dosage:50 mg/kg, 100 mg/kg
Administration:Oral administration (oral bolus dose)
Result:Exhibited potent antiretroviral activity.
Animal Model:Male beagle dogs (10-12 kg)
Dosage:100 mg/kg (Pharmacokinetic Analysis)
Administration:Oral administration
Result:The estimated average plasma Cmax and AUC values were 15.4 μM and 23.1 μM·h, respectively. The average elimination half-life (t1/2) and mean residence time (MRT) were 108.6 min and 119.4 min, respectively.
体外研究：
Stampidine (7.8-1,000 μM; 24 hours) is not cytotoxic to genital tract epithelial cells.Stampidine has no effect on sperm motility in cervical mucus.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备