产品
编 号：F614377
分子式：C14H10Cl4N2O
分子量：364.05
分子式：C14H10Cl4N2O
分子量：364.05
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规格
价格
是否有货
10mM*1mL in DMSO
询价
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 219315-22-7
产品详情
生物活性：
Mitochondrial fusion promoter M1 is a mitochondrial dynamic modulator. Mitochondrial fusion promoter M1 preserves the mitochondrial function and promotes cellular respiration. Mitochondrial fusion promoter M1 alleviates cardiac and brain damage in rats with cardiac ischemia/reperfusion injury.
体内研究：
Mitochondrial fusion promoter M1 (2 mg/kg；iv) 显著保护心脏 I/R 损伤大鼠免受脑损伤。Animal Model:Male Wistar rats (250-300g) receiving cardiac ischemia/reperfusion (I/R)
Dosage:2 mg/kg
Administration:I.v. 15 minutes before cardiac I/R injury
Result:Increased brain mitochondrial fusion.Increased blood-brain barrier (BBB) tight junction protein, and reduced macrophage in?ltration in the brain.Reduced brain mitochondrial dysfunction and apoptosis, but it did not reduce mitochondrial oxidative stress.Reduced the expression of Alzheimer’s disease (AD)-related proteins.
体外研究：
Mitochondrial fusion promoter M1 (5-25 μM；24 h) 促进 Mitofusin-1 和 Mitofusin-2 敲除成纤维细胞中的线粒体延伸。 Mitochondrial fusion promoter M1 (20 μM；12 h) 将线粒体 ROS 降低至 1.0±0.44 倍，将线粒体膜电位从 0.29±0.05 倍提高至 0.5±0.07 倍，并恢复 BRIN-BD11 胰腺 β 细胞中的线粒体结构。 Mitochondrial fusion promoter M1 (20 μM；12 h) 防止因胆固醇暴露引起的胰腺 β 细胞耗氧率受损。 Mitochondrial fusion promoter M1 (20 μM；12 h) 防止富含胆固醇的胰腺 β 细胞中非线粒体呼吸和细胞外酸化率 (ECAR) 受损。Mitochondrial fusion promoter M1 (20 μM；12 小时) 在胆固醇处理的胰腺 β 细胞中恢复葡萄糖刺激的胰岛素分泌 (GSIS)。
Mitochondrial fusion promoter M1 is a mitochondrial dynamic modulator. Mitochondrial fusion promoter M1 preserves the mitochondrial function and promotes cellular respiration. Mitochondrial fusion promoter M1 alleviates cardiac and brain damage in rats with cardiac ischemia/reperfusion injury.
体内研究：
Mitochondrial fusion promoter M1 (2 mg/kg；iv) 显著保护心脏 I/R 损伤大鼠免受脑损伤。Animal Model:Male Wistar rats (250-300g) receiving cardiac ischemia/reperfusion (I/R)
Dosage:2 mg/kg
Administration:I.v. 15 minutes before cardiac I/R injury
Result:Increased brain mitochondrial fusion.Increased blood-brain barrier (BBB) tight junction protein, and reduced macrophage in?ltration in the brain.Reduced brain mitochondrial dysfunction and apoptosis, but it did not reduce mitochondrial oxidative stress.Reduced the expression of Alzheimer’s disease (AD)-related proteins.
体外研究：
Mitochondrial fusion promoter M1 (5-25 μM；24 h) 促进 Mitofusin-1 和 Mitofusin-2 敲除成纤维细胞中的线粒体延伸。 Mitochondrial fusion promoter M1 (20 μM；12 h) 将线粒体 ROS 降低至 1.0±0.44 倍，将线粒体膜电位从 0.29±0.05 倍提高至 0.5±0.07 倍，并恢复 BRIN-BD11 胰腺 β 细胞中的线粒体结构。 Mitochondrial fusion promoter M1 (20 μM；12 h) 防止因胆固醇暴露引起的胰腺 β 细胞耗氧率受损。 Mitochondrial fusion promoter M1 (20 μM；12 h) 防止富含胆固醇的胰腺 β 细胞中非线粒体呼吸和细胞外酸化率 (ECAR) 受损。Mitochondrial fusion promoter M1 (20 μM；12 小时) 在胆固醇处理的胰腺 β 细胞中恢复葡萄糖刺激的胰岛素分泌 (GSIS)。
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