产品
编 号：F065279
分子式：C7H11N3O6S
分子量：265.24
分子式：C7H11N3O6S
分子量：265.24
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
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10mg
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50mg
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100mg
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结构图
CAS No: 1192500-31-4
产品详情
生物活性：
Avibactam (NXL-104) free acid is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC50s of 8 nM and 5 nM, respectively.
体内研究：
Ceftazidime-Avibactam (0.375?mg/g; s.c.; q8h for 10 days) has a significant effect on the bacteria and led to a certain therapeutic efficacy in K. pneumoniae strain Y8 infected mouse model.Avibactam (64 mg/kg; s.c.; once) shows mean estimated half-life in plasma in the terminal phase of 0.24 h in Pseudomonas aeruginosa infected neutropenic mice with lung infection.Animal Model:Six-week-old BALB/c mice (female), K. pneumoniae strain Y8 infection model
Dosage:0.375?mg/g in combination with Ceftazidime
Administration:Subcutaneous injection, 4?h post infection and given every 8?h for 10?days
Result:70% of infection group mice died within 4?days, and all mice in the PBS group died within 13?days. All treatment group mice survived at 10 days post infection with the antibiotic applied every 8?h, whereas 100% of mice in this group died within 4?days after the antibiotic treatment stopped. The spleen and liver of treatment group mice showed lower CFU counts, as compare with that of infected group.
体外研究：
Avibactam is a molecule with little antibacterial activity, that inhibits class A and C β-lactamases, but not metallo types and Acinetobacter OXA carbapenemases. Ceftazidime(HY-B0593)-Avibactam (0-256 mg/L) inhibits 16 blaKPC-2 positive and 1 of blaOXA-232 positive Klebsiella pneumonia growth with MIC50 and MIC90 for both 8?mg/L.
Avibactam (NXL-104) free acid is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC50s of 8 nM and 5 nM, respectively.
体内研究：
Ceftazidime-Avibactam (0.375?mg/g; s.c.; q8h for 10 days) has a significant effect on the bacteria and led to a certain therapeutic efficacy in K. pneumoniae strain Y8 infected mouse model.Avibactam (64 mg/kg; s.c.; once) shows mean estimated half-life in plasma in the terminal phase of 0.24 h in Pseudomonas aeruginosa infected neutropenic mice with lung infection.Animal Model:Six-week-old BALB/c mice (female), K. pneumoniae strain Y8 infection model
Dosage:0.375?mg/g in combination with Ceftazidime
Administration:Subcutaneous injection, 4?h post infection and given every 8?h for 10?days
Result:70% of infection group mice died within 4?days, and all mice in the PBS group died within 13?days. All treatment group mice survived at 10 days post infection with the antibiotic applied every 8?h, whereas 100% of mice in this group died within 4?days after the antibiotic treatment stopped. The spleen and liver of treatment group mice showed lower CFU counts, as compare with that of infected group.
体外研究：
Avibactam is a molecule with little antibacterial activity, that inhibits class A and C β-lactamases, but not metallo types and Acinetobacter OXA carbapenemases. Ceftazidime(HY-B0593)-Avibactam (0-256 mg/L) inhibits 16 blaKPC-2 positive and 1 of blaOXA-232 positive Klebsiella pneumonia growth with MIC50 and MIC90 for both 8?mg/L.
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